It's not the way Leland Oxley expected to launch his Gunbarrel restaurant, Motherlode. In less than two weeks he opened the new restaurant, closed down the dining room, started a carryout and delivery business and began room service for all of five guests staying at the nearby Hampton Suites hotel.

"At some point you just say it is what it is and make the best of it," said Oxley.

Motherlode isn't the only restaurant suffering after the coronavirus forced Gov. Jared Polis to limit all restaurants in the state to takeout and delivery. Oxley and other restaurant owners are laying off much of...